Research supported by the National Institutes of Health has found that measuring inflammation and lipids in midlife can predict a woman’s risk for cardiovascular disease later in life. The study followed 27,939 women for 30 years and found that high levels of LDL cholesterol, Lp(a), and CRP were associated with an increased risk of heart disease and stroke. When these three markers were assessed together, participants with the highest levels had over a 1.5-times increased risk for stroke and a three-times increased risk for coronary heart disease.
The researchers emphasize the importance of primary prevention strategies, including regular physical activity, a heart-healthy diet, stress management, and avoiding tobacco. Medication to lower cholesterol and reduce inflammation may also be recommended for those at increased risk. Screening for LDL cholesterol is routine, but recommendations for screening for Lp(a) and CRP vary. Colchicine and other anti-inflammatory therapies are being studied as potential treatments for cardiovascular disease.
The study was supported by grants from the NHLBI and the National Cancer Institute. The NHLBI conducts and supports research in heart, lung, and blood diseases to advance scientific knowledge and improve public health. The NIH, the nation’s medical research agency, supports research in various diseases and treatments. The research findings suggest that early measurement of inflammation and lipids may help identify individuals at risk for cardiovascular disease and guide preventive strategies and treatment options.
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