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Population-Based Cohort Study Examining the Relationship Between Serum Uric Acid Variability, Neuroimaging Metrics, and Cognitive Decline: Findings from BMC Medicine


The World Health Organization (WHO) has released a position paper on optimizing brain health across the lifespan, emphasizing the importance of maintaining cognitive function. Research has identified a link between serum uric acid levels and cognitive health, with higher levels associated with better executive function in men. However, conflicting results have been found in women, suggesting a complex relationship between uric acid and cognitive function.

Studies have also shown a U-shaped association between serum uric acid levels and cognitive function in patients with type 2 diabetes, indicating that both low and high levels may have negative effects on brain health. Additionally, research has demonstrated a relationship between uric acid levels and brain atrophy, cerebral white matter lesions, and cognitive decline.

Furthermore, the impact of lifestyle factors, such as body size, blood pressure, and sugar-sweetened beverage intake, on serum uric acid levels and cognitive function has been investigated. It has been found that these factors can modulate the relationship between uric acid and health outcomes.

Overall, the research highlights the importance of monitoring and managing serum uric acid levels to optimize brain health and reduce the risk of cognitive decline and dementia. By understanding the complex relationship between uric acid and cognitive function, interventions can be developed to support brain health and wellbeing.

Note: The image is for illustrative purposes only and is not the original image associated with the presented article. Due to copyright reasons, we are unable to use the original images. However, you can still enjoy the accurate and up-to-date content and information provided.

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